Microbiota Separation and C-reactive Protein Elevation in Treatment-naïve Pediatric Granulomatous Crohn Disease

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Abstract: In patients with inflammatory bowel diseases (IBDs), the presence of noncaseating mucosal granuloma is sufficient for diagnosing Crohn disease (CD) and may represent a specific immune response or microbial-host interaction. The cause of granulomas in CD is unknown and their association with the intestinal microbiota has not been addressed with high-throughput methodologies.

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